Nuclear reprogramming and stem cell creation
نویسندگان
چکیده
منابع مشابه
Colloquium Nuclear reprogramming and stem cell creation
The transplantation of a somatic cell nucleus to an enucleated egg results in a major reprogramming of gene expression and switch in cell fate. We review the efficiency of nuclear reprogramming by nuclear transfer. The serial transplantation of nuclei from defective first-transfer embryos and the grafting of cells from such embryos to normal host embryos greatly increases the proportion of nucl...
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Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
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1Renova Life Inc., University of Maryland, College Park, MD 20742, USA 2Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA 3Consorzio di Ricerca e Sperimentazione per gli Allevatori (CRSA), 00161 Rome, Italy 4Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan 5Department of Animal Science, National Pingtung University of Sc...
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Researchers have long suspected that cancer cells and stem cells share a core molecular signature, but this commonality remains incompletely understood. By examining microRNA (miRNA) expression patterns in multiple types of cancer cells and stem cells, Neveu et al. (2010) have now developed the miRMap, a tool that facilitates quantitative examination of the molecular hallmarks associated with a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1834207100